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Faculty : School of Bio-Chemical Engineering and Technology (BCET)
Name : Dr. Siwarutt Boonyarattanakalin (Assistant Professor)
Position : Assistant Professor
E - Mail : siwarutt.siit@gmail.com
siwarutt@siit.tu.ac.th
Phone Rangsit : +66 (0) 2986 9101, 2986 9009, 2564 3226
Phone Bangkadi :
Phone Extension : 2305
 
Education
  • B.S. in Chemistry (Distinction), Colorado State University, USA
  • Ph.D. in Organic Chemistry, The Pennsylvania State University, USA


Full Scholarship Opportunity in Chemical Engineering, Chemical Biology and Biotechnology ·Ø¹¡ÒÃÈÖ¡ÉÒ
Academic Awards
  • Research Grant Award, Thailand Toray Research Foundation
  • Best Thesis in Chemistry and Pharmacy, National Research Council of Thailand (NRCT)
  • Roche Research Foundation Postdoctoral Fellowship
  • Asian CORE Program (ACP) Lectureship Award for Japan
  • Asian CORE Program (ACP) Lectureship Award for Taiwan
Research Areas
    Design, synthesis, and evaluation of biologically active molecules. Design and validation of assays to evaluate biologically active molecules and assays to study cellular processes. Developments of biological and chemical methods for carbon recycles. Organic synthesis.
Research Interests

    Chemical Biology

    Chemical Biology has recently emerged as an exciting new field that focuses on problems and processes at the interface of chemistry and biology. Chemistry uniquely provides essential tools and techniques to study biological systems at the molecular level. Appropriate small synthetic molecules are very useful in studying and manipulating biological processes. Dr. Siwarutt’s research areas include design, synthesis and evaluation of biologically active molecules; and design and validation of assays to evaluate biologically active molecules and to study cellular processes.

    Synthesis

    Our research has focused on developments of alternative chemical methods for rapid and efficient syntheses of compounds for therapeutic and material purposes. The robust synthetic protocols allow access to a large scale quantity of novel compounds. The synthetic compounds provide tools for physical and biological studies.

    Developments of Chemical and Biological Methods for Carbon Recycles

    Industrial wastes increasingly have become a financial burden for many production processes. We are investigating ways to recycle these wastes and make them become resources. Both biological and chemical methods offer potential protocols to recycle wastes.

 
Work Experiences
  • 2008-Present: SIIT.
  • 2006-2008: Postdoctoral Fellow, Swiss Federal Institute of Technology (Eidgenössische Technische Hochschule, ETH Zurich), Zurich, Switzerland.
List of Publications
International Journals
  1. Boonyarattanakalin, S.; Ruchirawat, S.; and Gleeson, M. P. “Ring opening polymerization of mannosyl tricyclic orthoesters: retionalising the stereo and regioselectivity of glycosidic bond formation using quantum chemical calculations”, MedChemComm 2013, 4 (1), 265-268.
  2. Yongyat, C.; Ruchirawat, S.; and Boonyarattanakalin, S. “Polymerization of Mannosyl Tricyclic Orthoesters for the Synthesis of α(1–6) Mannopyranan—the Backbone of Lipomannan”, Bioorgan. Med. Chem. 2010, 18 (11), 3726-3734.
  3. Kikkeri, R.; Kamena, F.; Gupta, T.; Hossain, L. H.; Boonyarattanakalin, S.; Gorodyska, G.; Beurer, E.; Coullerez, G.; Textor, M.; and Seeberger, P. H. “Ru(II) Glycodendrimers as Probes to Study Lectin-Carbohydrate Interactions and Electrochemically Measure Monosaccharide and Oligosaccharide Concentrations” Langmuir Lett. 2010, 26 (3), 1520-1523.
  4. Boonyarattanakalin, S.; Liu, X.; Michieletti, M.; Lepenies, B.; and Seeberger, P. H. “Chemical Synthesis of All Phosphatidylinositol Mannoside (PIM) Glycans from Mycobacterium tuberculosis” J. Am. Chem. Soc. 2008, 130, 16791-16799.
  5. Liu, X.; Wada, R.; Boonyarattanakalin, S.; Castagnera, B.; Seeberger, P. H. “Automated Synthesis of Lipomannan Backbone α(1-6) Oligomannoside via Glycosyl Phosphate: Glycosyl Tricyclic Orthoester Revisited” Chem. Commun. (Cambridge, U. K.), 2008, 3510-3512.
  6. Boonyarattanakalin, S.; Hu, J.; Dykstra-Rummel, S.; August, A.; and Peterson, B. R. “Endocytic Delivery of Vancomycin Mediated by a Synthetic Cell Surface Receptor: Rescue of Bacterially Infected Mammalian Cells and Tissue Targeting In Vivo” J. Am. Chem. Soc. 2007, 129, 268-269.
  7. Boonyarattanakalin, S.; Martin, S. E.; Sun, Q. and Peterson, B. R. “A Synthetic Mimic of Human Fc Receptors: Defined Chemical Modification of Cell Surfaces Enables Efficient Endocytic Uptake of Human Immunoglobulin-G” J. Am. Chem. Soc. 2006, 128, 11463-11470.
  8. Boonyarattanakalin, S.; Athavankar, S.; Sun, Q. and Peterson, B. R. “Synthesis of an Artificial Cell Surface Receptor that Enables Oligohistidine Affinity Tags to Function as Metal-Dependent Cell-Penetrating Peptides” J. Am. Chem. Soc. 2006, 128, 386-387.
  9. Mottram, L.; Boonyarattanakalin, S.; Kovel, R. E. and Peterson, B. R. “The Pennsylvania Green Fluorophore: A Hybrid of Oregon Green and Tokyo Green for the Construction of Hydrophobic and pH-Insensitive Molecular Probes” Org. Lett. 2006, 8, 581-584.*
    *This article was highlighted in News Highlight of Chemical and Engineering News: “New Fluorescein Adds to Cellular Probe Arsenal” Chem. Eng. News, 2006, 84, 33.
  10. Boonyarattanakalin, S.; Martin, S. E.; Dykstra, S. A.; and Peterson, B. R. “Synthetic Mimics of Small Mammalian Cell Surface Receptors” J. Am. Chem. Soc. 2004, 126, 16379-16386.**
    **This article was highlighted in Research Highlights of Nature Methods: Rusk, N. “Alternatives to a Horse” Nature Methods, 2005, 2, 88-89.
International Conferences
  1. Hutacharoen, P.; Ruchirawat, S.; and Boonyarattanakalin, S., “Synthetic preparation of β-D-arabinofuranose 1,2,5-α-(1→5) arabinofuranose ring-opening polymerization.” Proceedings of the 6th Pure and Applied Chemistry International Conference 2012 (PACCON 2012) [CD-ROM], 11-13 January 2012, Chiang Mai, Thailand, 1753-1756.
  2. Tangsangasaksri, M.; Punarnunnon, T.; Yukphan, P.; Chaipitakchonlatarn, W.; and Boonyarattanakalin, S., “Identification of microflora in milk kefir in Thailand.” Proceedings of the 6th Pure and Applied Chemistry International Conference 2012 (PACCON 2012) [CD-ROM], 11-13 January 2012, Chiang Mai, Thailand, 813-815.
  3. Leelayuwapan, H.; Siwanartnusorn, K.; Wattanasiri, C.; Ruchirawat, S.; and Boonyarattanakalin, S., “Rapid synthesis of polymannan with thiol linker for adlayer self assembly on a gold surface.” Proceedings of the 6th Pure and Applied Chemistry International Conference 2012 (PACCON 2012) [CD-ROM], 11-13 January 2012, Chiang Mai, Thailand, 1745-1748.
  4. Wattanasiri, C.; Ruchirawat, S.; and Boonyarattanakalin, S., “Synthesis of a mannose building block acceptor for 1,2-glycosidic linkages.” Proceedings of the 6th Pure and Applied Chemistry International Conference 2012 (PACCON 2012) [CD-ROM], 11-13 January 2012, Chiang Mai, Thailand, 1772-1775.
  5. Sungsilp, M., Yongyat, C., Ruchirawat, S. and Boonyarattanakalin, S. “Synthesis of tricyclic orthoesters of mannose for ring-opening oligomerization toward d-mannopyranan”. Proceedings of Pure and Applied Chemistry International Conference (PACCON 2010), 21-23 January 2010, Ubon Ratchathani, Thailand, 760-763.
  6. Boonyarattanakalin, S. and Seeberger, P. H. “Convergent Synthesis of Phosphatidylinositol Hexamannoside Glycan of Mycobacterium tuberculosis”. Proceedings of the Pure and Applied Chemistry International Conference (PACCON 2009), 14-16 January 2009, Phitsanulok, Thailand, 446-449.
 
 
 
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